Affinity Groups
| Logo | Name | Description | Tags | Join |
|---|---|---|---|---|
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Open OnDemand | An intuitive, innovative, and interactive interface to remote computing resources.Open OnDemand helps computational researchers and students efficiently utilize remote computing resources by making… | open-ondemandadministering-hpccluster-management +4 more tags | Login to join |
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Account and Access Management CI Facilitators | A group for CI and RCD professionals responsible for developing and maintaining the Account and Access Management solutions used at their institutions. Participants are invited to share and discuss… | allocation-managementadministering-hpc | Login to join |
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hpc.social | High Performance Computing and related fields, including Big Data, Research Computing, and related hardware and software optimized for these fields, including research software engineering and… | administering-hpccluster-managementcluster-support +6 more tags | Login to join |
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Knowledge Base Resources
| Title | Category | Tags | Skill Level |
|---|---|---|---|
| Containerized Jupyter Notebooks for HPCs | Learning | cloudcloud-computingopenstack +20 more tags | Intermediate |
| High performance computing 101 | Website | administering-hpc | Beginner |
| Hour of Ci | Learning | arcgisgeographic-information-systemadministering-hpc | Beginner |
Engagements
Recruiting
Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
- Summary and objectives of the proposed experiments:
- An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
- Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
- Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
- Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: Recruiting
People with Expertise
Nick Dusek
North Dakota State University
Programs
Campus Champions
Roles
research computing facilitator, ci systems engineer
Expertise
Chris Reidy
University of Arizona
Programs
Campus Champions, CCMNet
Roles
mentor, research computing facilitator, CCMNet
Expertise
Expertise
People with Interest
Interests
Jeff Falgout
United States Geological Survey
Programs
Campus Champions, RMACC
Roles
research computing facilitator, ci systems engineer
Interests
Michael Weiner
Georgia Institute of Technology
Programs
Campus Champions
Roles
CampusChampionsAdmin, research computing facilitator, Affinity Group Leader
