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Engagements
Recruiting
Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
- Summary and objectives of the proposed experiments:
- An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
- Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
- Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
- Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: Recruiting
People with Expertise
Christina Divoll
Tufts University
Programs
Campus Champions, ACCESS CSSN
Roles
research computing facilitator
Expertise
Katherine Nelson
Yale University
Programs
Campus Champions, CAREERS, ACCESS CSSN
Roles
mentor, administrator, Masquerade, ExportPeople, research computing facilitator, steering committee, regional admin
Expertise
Expertise
People with Interest
Rachael Auch
South Dakota State University
Programs
Great Plains, Campus Champions, CCMNet
Roles
mentor, research computing facilitator, regional admin, CCMNet
Interests
Interests
