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Knowledge Base Resources
| Title | Category | Tags | Skill Level |
|---|---|---|---|
| Advanced Compilers: The Self-Guided Online Course | Learning | optimizationparallelizationtraining +1 more tags | Advanced |
| Advanced Mathematical Optimization Techniques | Learning | optimizationpython | Beginner, Intermediate, Advanced |
| Fine-tuning LLMs with PEFT and LoRA | Video | fasteroptimizationperformance-tuning +1 more tags | Intermediate, Advanced |
Engagements
Recruiting
Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
- Summary and objectives of the proposed experiments:
- An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
- Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
- Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
- Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: Recruiting
People with Expertise
Katia Bulekova
Boston University
Programs
ACCESS CSSN, Campus Champions, CAREERS, CCMNet, Northeast
Roles
mentor, research computing facilitator, CCMNet
Expertise
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