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Upcoming Events & Trainings
| Title | Date |
|---|---|
| 2025 UCAR Improving Scientific Software Conference | 4/07/25 |
Topics from Ask.CI
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Knowledge Base Resources
| Title | Category | Tags | Skill Level |
|---|---|---|---|
| Intro to GenAI Chatbot | Learning | aigenerative-ai | Beginner |
| Leveraging AI in Generative Assets and Environments for Play: Insights from the English Department's Digital Media Lab | Slides | aiLLMgenerative-ai +8 more tags | Beginner |
| Tutorial: Localized RAG Chatbot with ACCESS HPC | Tool | aiLLMgenerative-ai +17 more tags | Beginner, Intermediate |
Engagements
Recruiting
Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
- Summary and objectives of the proposed experiments:
- An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
- Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
- Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
- Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: Recruiting
People with Expertise
Expertise
Expertise
Feseha Abebe-Akele
Elizabeth City State University
Programs
CCMNet
Roles
mentor, researcher/educator, research computing facilitator, CCMNet
Expertise
People with Interest
Programs
CCMNet
Roles
CCMNet
Interests
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